HEMOPERFUSION USING THE LPS-SELECTIVE MESOPOROUS POLYMERIC ADSORBENT IN SEPTIC SHOCK: A MULTICENTER RANDOMIZED CLINICAL TRIAL
This multicenter randomized controlled trial evaluated the efficacy and safety of Efferon LPS hemoperfusion cartridges in patients with intra-abdominal sepsis (IAS) and septic shock. The study included a group undergoing EHP procedures (n = 38) and a control group receiving conventional protocols (n = 20). EHP resulted in significant improvements, including increased mean arterial pressure (MAP) and partial pressure arterial oxygen/fraction of inspired oxygen ratio (PaO2/FiO2), decreased norepinephrine doses, and improved multiorgan function based on Sequential Organ Failure Assessment (SOFA) scores. Notably, EHP facilitated faster weaning from mechanical ventilation. Early 3-day mortality was reduced in the Efferon LPS group, and laboratory tests showed rapid normalization of biomarkers. These findings demonstrate that EHP with Efferon LPS is a safe procedure for resolving septic shock and restoring clinical biomarkers in IAS patients.
Rey S, Kulabukhov VM, Popov A, Nikitina O, Berdnikov G, Magomedov M, Kim T, Masolitin S, Ignatenko O, Krotenko N, Marysheva A, Chaus N, Ohinko L, Mendibaev M, Chumachenko A, Pisarev V. HEMOPERFUSION USING THE LPS-SELECTIVE MESOPOROUS POLYMERIC ADSORBENT IN SEPTIC SHOCK: A MULTICENTER RANDOMIZED CLINICAL TRIAL. Shock. 2023 Jun 1;59(6):846-854. doi: 10.1097/SHK.0000000000002121. Epub 2023 Apr 6. PMID: 37018802. Link