Respiratory Failure & Mechanical Ventilation

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Differential Effect of Positive End-Expiratory Pressure Strategies in Patients With ARDS - CHEST

This analysis of data from the ALVEOLI and ART trials, involving 1,559 ARDS patients, identified differential responses to PEEP strategies based on two ARDS subphenotypes. Higher PEEP was associated with increased 28-day mortality in subphenotype A (OR 1.61 in ALVEOLI; OR 1.73 in ART), with a high probability of harm (94.3% and 97.7%, respectively). In subphenotype B, no significant association between PEEP and mortality was observed. These findings suggest that PEEP strategies may need to be tailored to ARDS subphenotypes, guiding future clinical trial designs and individualized treatments.

PEEP

Oct 25

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Dear Dr. Mazen,

Excellent presentation and case. Jazak Allah Khair ❤️.

Edited

dr.nawaf

22 days ago

Pioneer

43 year old man with hiv,pjp and pneumothorax with chest tube, on VVECMO ,love to hear your comments

mohammed albesh

Oct 23

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there is signs of air leakage. but regarding the Ecmo is it feasible to increase the flow more to improve the hypoximia , Besides it appeeaes from Arterial waves that there is may be significant PPV could we push some fluids to improve flow and preload

additionaly in the context of HIV patients with multiple bullae and pneumothorax > any role here for steroid and sulfa/trimeth. for pneumocytsis. jorvtici