Differential Effect of Positive End-Expiratory Pressure Strategies in Patients With ARDS - CHEST
This analysis of data from the ALVEOLI and ART trials, involving 1,559 ARDS patients, identified differential responses to PEEP strategies based on two ARDS subphenotypes. Higher PEEP was associated with increased 28-day mortality in subphenotype A (OR 1.61 in ALVEOLI; OR 1.73 in ART), with a high probability of harm (94.3% and 97.7%, respectively). In subphenotype B, no significant association between PEEP and mortality was observed. These findings suggest that PEEP strategies may need to be tailored to ARDS subphenotypes, guiding future clinical trial designs and individualized treatments.
