Respiratory Failure & Mechanical Ventilation

HOT COVID Trial

Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial | Coronavirus (COVID-19) | JAMA | JAMA Network

In a multicenter trial involving 726 adults with COVID-19 and severe hypoxemia in European ICUs, targeting a partial pressure of oxygen (Pao2) of 60 mm Hg led to a median of 80 days alive without life support at 90 days, compared to 72 days for a Pao2 of 90 mm Hg (P=.009). No significant difference in mortality or serious adverse events was observed between the groups. This suggests that in severe COVID-19, a lower oxygenation target may improve outcomes without increasing risk.