The respiratory drive is the intensity of the neural stimulus that determines how much the respiratory muscles contract. Excessive or low respiratory drive can be encountered in different clinical scenarios in patients on mechanical ventilation. High respiratory drive potentially leads to an injurious effect on the diaphragm (myotrauma), and on the lung (patient-self-inflicted lung injury). The low respiratory drive may cause disuse atrophy which leads to difficulty in weaning off the ventilator. Occlusion pressure at 100 ms (P 0.1) is the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit and has been used as an indirect measure of the respiratory drive.
Please observe the P0.1 procedure and value in the. Above graph and provide your answer to this question:
What does a value of P0.1 of -3.5 indicate?
0%High respiratory drive
0%Normal respiratory drive
0%Low respiratory drive
0%Weak respiratory muscles
Sources of errors and potential pitfalls
There is a significant breath-to-breath variability of P0.1, and an average of 3–4 values of P0.1 in one patient in one clinical condition should be obtained to represent a reli- able index of respiratory drive . Range of values
In healthy subjects, P0.1 varies between 0.5 and 1.5 cmH2O . In stable, non-intubated patients with COPD, P0.1 varies between 2.5 and 5.0 cmH2O [3]. Ranges of P0.1 from 3.0 to 6.0 cmH2O have been reported in patients with ARDS under mechanical ventilation, and from 1.0 to as high as 13 cmH2O during weaning.