Infectious Disease & Sepsis

Public·414 members

March 15, 2023

De-resuscitation in septic shock refers to the process of actively removing excess fluids from a patient after their condition has been stabilized. Does this improve outcomes?

Turning the Tide: Can Active Fluid De-resuscitation Enhance Outcomes in Septic Shock Patients?

Management

Mazen Kherallah

March 13, 2023

The Clinical Significance of Anaerobic Coverage in the Antibiotic Treatment of Aspiration Pneumonia: A Systematic Review and Meta-Analysis

This article is a systematic review and meta-analysis of studies that compared antibiotics with and without anaerobic coverage in the treatment of aspiration pneumonia. The authors found that anaerobic coverage did not improve mortality, resolution of pneumonia, length of hospital stay, recurrence of pneumonia, or adverse effects. They concluded that anaerobic coverage is not recommended in the treatment of aspiration pneumonia based on current data.

(A) Mortality; (B) Clinical cure rate. Forest plots comparing outcomes in groups given antibiotic treatment with or without anaerobic coverage. The blue square represents the odds ratios of individual studies. The black diamond represents the pooled result.

Yoshimatsu, Y.; Aga, M.; Komiya, K.; Haranaga, S.; Numata, Y.; Miki, M.; Higa, F.; Senda, K.; Teramoto, S. The Clinical Significance of Anaerobic Coverage in the Antibiotic Treatment of Aspiration Pneumonia: A Systematic Review and Meta-Analysis. J. Clin. Med.2023, 12, 1992. https://doi.org/10.3390/jcm12051992

Mazen Kherallah

March 12, 2023 · added an event.

Nebulized Antibiotics for Ventilator-Associated Pneumonia: What is the best song...

March 17, 2023, 9:00 – 10:00 PM GMT+4|Zoom Meeting (Dubai Time)

Mazen Kherallah

February 5, 2023

Recently published in the journal of critical care medicine a systematic review and meta-analysis that aimed to determine whether targeting a higher mean arterial pressure (MAP) in adults with shock results in differences in important patient outcomes compared to a lower MAP.

The study used various data sources and the eligibility criteria included parallel-group randomized controlled trials in adult patients with a diagnosis of shock requiring vasoactive medications. The higher MAP group was required to receive vasoactive medications to target a higher MAP, whereas the lower MAP group received vasoactive medications to target a lower MAP.

Data from six randomized controlled trials were analyzed and showed that targeting a higher MAP (75–85 mm Hg) compared to a lower MAP of 65 mm Hg resulted in no difference in mortality (moderate certainty) but may reduce the risk of undergoing renal replacement therapy in patients with chronic hypertension. Further studies are needed to explor…