Which of the following organisms grows as black colonies on blood agar?
Corynebacterium
Staphylococcus aureus
Escherichia coli
Pseudomonas aeruginosa
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Infectious Disease & Sepsis
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In another small study vitamin C monotherapy failed to significantly reduce mortality in septic shock patients as hypothesized.
Phenylephrine versus Norepinephrine in Septic Shock
Phenylephrine, a pure α-agonist with vasoconstrictive effects similar to norepinephrine, but without chronotropic or inotropic effects. This leads to increased afterload, reflex bradycardia, and possibly a drop in the cardiac output.
A small study of 32 patients showed that there is no differences in terms of cardiopulmonary performance, global oxygen transport, and regional hemodynamics when compared with norepinephrine. However, it is not recommended as an initial vasopressor due to its potential association with reduced splanchnic blood flow in septic shock patients. \
During the shortage of norepinephrine in the US in 2011, a cohort study of 27,835 patients revealed an association between the norepinephrine shortage and mortality among adults with septic shock, during this period, the most commonly administered alternative vasopressor was phenylephrine.
Therefore, we discourage the use of phenylephrine in general. If used, we recommend to limit it to patients who:
develop tachyarrhythmias…
What results do you anticipate of CLASSIC trial (Restrictive Fluids in Septic Shock) ?
Restrictive strategy is better than usual care
No difference
Restrictive strategy is worse than usual care
Mazen Kherallah
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Thank you for your votes!
The CLASSIC trial results will be published in June 15, 2022 at the critical care reviews meeting in Belfast. I will upload the visual abstract to the trials section of this website as soon as I get it.
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Thank you, the majority got it right, it is Corynebacterium