What results do you anticipate of CLASSIC trial (Restrictive Fluids in Septic Shock) ?
Restrictive strategy is better than usual care
No difference
Restrictive strategy is worse than usual care
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Infectious Disease & Sepsis
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The 30 mL/kg fluid resuscitation to all patients as per surviving sepsis campaign guidelines has been challenged in a nice article by Paul Marik that you may be interested to look at here:
The conclusion suggested that an individualized, hemodynamically guided and fluid restricted approach to fluid therapy will improve the outcomes of patients with severe sepsis and septic shock.
I think the CLASSIC trial (Restrictive Fluid in Septic Shock) results will be released in June and will shed more light on the topic before any change in the guidelines.
A meta-analysis published on April 15, 2022 compared prognostic accuracy of quick Sequential Organ Failure Assessment (qSOFA) score, Systemic Inflammatory Response Syndrome (SIRS) criteria, and National Early Warning Score (NEWS) with the aim to predict mortality in patients with suspected sepsis.
qSOFA showed higher overall prognostic accuracy than SIRS and NEWS. However, no scoring system has both high sensitivity and specificity for predicting the accuracy of mortality in patients with suspected sepsis.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0266755
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- abdullah alghamdi
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The CLASSIC trial results will be published in June 15, 2022 at the critical care reviews meeting in Belfast. I will upload the visual abstract to the trials section of this website as soon as I get it.
https://www.icureach.com/criticalcaretrials