This study investigated the link between laboratory-confirmed influenza and acute myocardial infarction (AMI). Using data from 158,777 PCR tests across the Netherlands, including 26,221 positive for influenza, 406 AMI episodes were analyzed. AMI incidence was significantly higher during the risk period (days 1-7 post-influenza) with an adjusted relative incidence of 6.16 (95% CI, 4.11 to 9.24). The risk was notably higher in those without prior coronary artery disease hospitalization (relative incidence 16.60; 95% CI, 10.45 to 26.37) compared to those with prior coronary artery disease (relative incidence 1.43; 95% CI, 0.53 to 3.84).
Influenza Infection and Acute Myocardial Infarction | NEJM Evidence