Peripheral Administration of Norepinephrine
This prospective observational cohort study conducted in the medical ICU of a quaternary care academic center evaluated the safety and effectiveness of a protocol for peripheral norepinephrine administration, aiming to reduce central venous catheter (CVC) use. Including adult patients from February 2019 to June 2021, findings revealed a median reduction of 1 CVC day per patient, with 51.6% avoiding CVC insertion altogether. Despite 75.8 extravasation events per 1,000 days of peripheral intravenous catheter (PIVC) infusion, most cases resulted in minimal or no tissue injury, and no surgical interventions were required. These results suggest that peripheral administration of norepinephrine can be a safe, viable alternative to traditional CVC use, potentially minimizing associated risks and complications in the ICU setting, and highlight the need for further multicenter studies to validate these findings.
Please note that the protocol of the study dictates that If the maximum allowable dose (15…
What the maximum duration of norepinephrine use through peripheral line in your hospital?
24 hours
48 hours
No limit
Very beautiful demonstration
It helps to suggest offloading rather than fluid resuscitation
It requires stady hands and minimal pt movement (abd wise) in order to catch the image in PW mode
If my memory serves me right, there were only limited data from multiple case report
No strong data to suggest outcome
Yet a useful tool to add on for the management
If we have research, i think mortality outcome, Cr trend, O2 requirements, vasopressors doses would be excellent markers for monitoring
Thank you Dr Mazen for your amazing continuous contribution to enriching our knowledge