General Critical Care

Pharmacotherapy for Reducing RBC Transfusion for Patients in... : Critical Care Medicine (lww.com)

This systematic review and network meta-analysis in Critical Care Medicine (April 2024) assessed therapies to reduce RBC transfusion needs in ICU patients. Searching MEDLINE, CENTRAL, and Embase until July 2023, it included 75 studies with 15,091 patients. Combination therapy of erythropoiesis-stimulating agents (Epo) and iron was found to notably decrease transfusion requirements (RR: 0.60; moderate confidence), outperforming Epo or iron monotherapy (RR: 0.81 and 0.83; low confidence, respectively). No significant increase in venous thromboembolism or infection risks was associated with combination therapy. In contrast, Epo alone might increase infection risks. The efficacy of vitamin D3 and HIF-PHI remains unclear.

The latest literature in critical care at:

https://www.icureach.com/so/3aOuVVCz8?languageTag=en&utm_source=facebook&utm_medium=wix-email-market

Complication Rates of Central Venous Catheters: A Systematic Review and Meta-Analysis | Medical Devices and Equipment | JAMA Internal Medicine | JAMA Network

Researchers conducted a systematic review and meta-analysis of 130 observational and randomized studies spanning from 2015 to 2023 to estimate the complication rate associated with central venous catheters (CVCs) in adult inpatients. The study excluded peripherally inserted central venous catheters, dialysis catheters, long-term tunneled catheters, and catheters placed by radiologists.

The analysis revealed that the three most common complications related to CVC insertions were placement failure (20.4 events per 1000 catheters placed), arterial puncture (16.2 events per 1000 catheters placed), and pneumothorax (4.4 events per 1000 catheters placed). The composite outcome of four serious complications (arterial cannulation, pneumothorax, infection, and deep venous thrombosis) from a CVC placed for 3 days was estimated to occur at a rate of 30 events per 1000 catheters placed, translating to approximately…

https://journals.lww.com/hep/abstract/9900/tranexamic_acid_in_upper_gastrointestinal_bleed_in.771.aspx