General Critical Care

https://www.nejm.org/doi/10.1056/NEJMoa2314063

https://www.nejm.org/doi/10.1056/NEJMoa2313040

Individualized Blood Pressure Management During Endovascular Treatment of Acute Ischemic Stroke Under Procedural Sedation"

The INDIVIDUATE study, conducted at a tertiary care university hospital, investigated whether a personalized blood pressure approach during endovascular stroke treatment offers better outcomes than standardized systolic blood pressure (SBP) targets. Patients with acute ischemic stroke were either assigned to individualized blood pressure management, targeting pre-intervention baseline SBP, or a standard protocol maintaining SBP between 140 and 180 mmHg. The primary outcome was the proportion of patients with favorable functional outcomes at 90 days post-stroke (measured as a modified Rankin Scale score of 0 to 2).

Of the 250 patients studied, the mean intraprocedural SBP showed no significant difference between the individualized and standard groups (P=0.16). Likewise, the proportion of patients with favorable functional outcomes at 90 days post-stroke was comparable: 25% in the individualized group and 24% in the standard group (P=0.56). Consequently, individualized SBP…