In a multi-center, double-blind randomized trial across eight Dutch ICUs, 132 critically ill adults with delirium were administered intravenous haloperidol or placebo, resulting in no significant difference in delirium- and coma-free days. The study, which was terminated early for futility, also found haloperidol might decrease the need for benzodiazepines and reduce agitation-related behaviors, although these secondary outcomes were not statistically conclusive.
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General Critical Care
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Published June 1, 2022 in the Intensive Care Medicine: The use of dexmedetomidine compared to other sedatives, resulted in a lower risk of delirium, and a modest reduction in duration of mechanical ventilation and ICU stay, but increased the risks of bradycardia and hypotension in mechanically ventilated adults.
What is the primary agent that you use to sedate your ventilated patients?
0%Dexmedetomidine
0%Propofol
0%Midazolam
You can vote for more than one answer.
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You can use dexmedetomidine or propofol to achieve light sedation for the majority of your patients in ICU who do not have indications for deeper sedation.