Which Oral Antibiotics Are Associated Most Strongly with Serious Cutaneous Drug Reactions (select up to two antibiotic groups)?
0%Ceohalosporins
0%Sulfonamides
0%Nitrofurantoin
0%Fluoroquinolones
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General Critical Care
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- Hussain Al-shabib
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This nested case-control study examined the risk of serious cutaneous adverse drug reactions (cADRs) among older adults in Ontario, Canada, following oral antibiotic use. Analyzing data from 2002-2022, the study found that sulfonamides (aOR, 2.9) and cephalosporins (aOR, 2.6) were most strongly associated with cADRs, with the highest crude rates of ED visits/hospitalizations. The study emphasizes the importance of prescribing lower-risk antibiotics, such as macrolides, when appropriate.
https://jamanetwork.com/journals/jama/fullarticle/2822097