Results of the COVID-PACT Trial:
•Hospitalized patients in the ICU who were treated with full-dose anticoagulation for acute COVID-19 had significantly fewer thrombotic events and complications compared to those who received standard-dose anticoagulation prophylaxis, but also experienced more moderate and severe bleeding events. However, mortality was not different.
• The findings from the COVID-PACT trial in an exclusively US-based cohort of 382 on-treatment patients in the ICU with COVID. The study was stopped early due to slow recruitment but still powerful to detect difference in the measured outcome.
Will this study change your practice and start using full anticoagulation on critically-ill patients in the ICU?
Yes
No
I will wait for the guidelines!
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https://pubmed.ncbi.nlm.nih.gov/36036760/