In a systematic review of 15 randomized clinical trials comparing the efficacy and safety of early active mobilization with usual care in critically ill adults. The primary outcome was days alive and out of hospital within 180 days, with a result of an increase of 4.28 days in the active mobilization group. The intervention also improved physical function in survivors at 6 months with a 95.1% probability. However, there is a possibility of increased adverse events and 6-month mortality with early active mobilization.
https://evidence.nejm.org/doi/full/10.1056/EVIDoa2200234
